Claire and her older brother Chris are children living at the Raccoon City Orphanage. Claire befriends Lisa Trevor, a disfigured girl who has been experimented on by Dr. William Birkin, an employee for the Umbrella Corporation, who oversees the orphanage and takes children for his own experimental research. Claire escapes from Birkin when she is selected to participate in an experiment. In 1998, Claire returns to Raccoon City, hitchhiking in a semi-truck, to visit her brother Chris. But something happened.